p-Toluenesulfonic acid → (3'aR,6'aS)-hexahydro-1'H-spiro(1,3-dioxolane-2,2'-pentalen)-5'-one

A mixture of 53.9 g of 3,3,7,7-diethylenedioxy-cis-bicyclo[3.3.0]octane as prepared in Referential Example 1, 2.26 g of p-toluenesulfonic acid and 500 ml of acetone-water (3:1) was stirred at room temperature for 1 hour and 40 minutes. Then, to the mixture was added 50 ml of saturated aqueous sodium hydrogencarbonate solution, the deposited crystals was filtered off and acetone was removed in vacuo from the filtrate, and the residue was extracted with chloroform. The organic layer was washed with saturated brine, dried over sodium sulfate, and concentrated. To the residue was added to 50 ml of a mixture of n-hexane/diethyl ether (1:1) and then crystals were deposited. After separating out the crystals by filtration, the filtrate was concentrated, and the residue was purified by silica gel chromatography (eluting solution: 20-30% (v/v) ethyl acetate/n-hexane) to obtain 20.4 g of the oily title compound.

1. filtrationthe deposited crystals was filtered off
2. customacetone was removed in vacuo from the filtrate
3. extractionthe residue was extracted with chloroform
4. washThe organic layer was washed with saturated brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated
7. additionTo the residue was added to 50 ml of a mixture of n-hexane/diethyl ether (1:1)
8. customAfter separating out the crystals by filtration
9. concentrationthe filtrate was concentrated
10. customthe residue was purified by silica gel chromatography (eluting solution: 20-30% (v/v) ethyl acetate/n-hexane)

ORD record

ord-1d4ac2be22f44f26936d095fff97b329

Source dataset

uspto-grants-1989_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04885246