反应详情

4.8 g of 3-[2-(piperazin-1-yl)ethylmercapto]1,2,4-triazolo(4,3-a)pyridine, prepared in Example 79, and 2.1 g of 2-chloropyrimidine are heated under reflux in 140 ml of isopropanol in the presence of 2.5 g of potassium carbonate. After heating for 2 hours, the medium is cooled, the mineral substances are filtered off and the filtrate is concentrated. The oily residue is filtered on silica gel (eluent: chloroform/methanol 90/10). The resulting residue crystallizes from an ethyl ether/isopropyl ether mixture to give 2.8 g of 3-[2-(4-(pyrimidin-2-yl)piperazin-1-yl)ethylmercapto]1,2,4-triazolo(4,3-a)pyridine in the form of crystals melting at 126°-7° C.

1. temperatureare heated
2. temperatureAfter heating for 2 hours
3. temperaturethe medium is cooled
4. filtrationthe mineral substances are filtered off
5. concentrationthe filtrate is concentrated
6. filtrationThe oily residue is filtered on silica gel (eluent: chloroform/methanol 90/10)
7. customThe resulting residue crystallizes from an ethyl ether/isopropyl ether mixture