反应详情

Prepared by analogy to Example 13 by reaction of 2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine with 1-(4-carbomethoxymethoxyphenyl)propan-2-one and sodium cyanoborohydride in methanol (reaction time: 5 hours) followed by purification on a silica gel column using methylene chloride/methanol=20:1. This results in a 50:50 diastereomer mixture of the base. This is recrystallised from a mixture of ether/ethyl acetate=65:10. The mother liquor resulting from this is mixed with ethereal hydrochloric acid, and the mixture is evaporated to dryness. The residue resulting from this is recrystallised from a mixture of ether/ethyl acetate/methanol=100:60:1. The mother liquor obtar,ned after the crystals have been removed by filtration is evaporated to dryness, and the base is liberated by shaking with alkali and methylene chloride and purified on a silica gel column using methylene chloride/methanol=20:1 as eluant. This results in diastereomer B as an oil approximately 92-94% pure.

1. customfollowed by purification on a silica gel column
2. customThis results in a 50:50 diastereomer mixture of the base
3. customThis is recrystallised from a mixture of ether/ethyl acetate=65:10
4. customThe mother liquor resulting from
5. customthe mixture is evaporated to dryness
6. customThe residue resulting from
7. customthis is recrystallised from a mixture of ether/ethyl acetate/methanol=100:60:1
8. customhave been removed by filtration
9. customis evaporated to dryness
10. custompurified on a silica gel column