反应详情

A solution of 3-(4-{2-[(bicyclo[4.2.0]octa-1(6),2,4-triene-7-carbonyl)-heptyl-amino]-ethyl}-phenyl)-2-ethoxy-propionic acid methyl ester (96 mg, 0.20 mmol) and 1 M LiOH (0.60 mmol, 0.60 mL) in tetrahydrofuran (3 mL) was allowed to stir at room temperature for 16 hours. 2 N HCL was then added until the solution had a pH<2. After dilution with twice its volume in water, the aqueous layer was extracted with diethyl ether (2×). The organic layers were combined, washed with 2 M HCl (2×), dried over anhydrous sodium sulfate, and concentrated to give 3-(4-{2-[(bicyclo[4.2.0]octa-1(6),2,4-triene-7-carbonyl)-heptyl-amino]-ethyl}-phenyl)-2-ethoxy-propionic acid as a clear oil (56 mg, 60%).

1. addition2 N HCL was then added until the solution
2. extractionAfter dilution with twice its volume in water, the aqueous layer was extracted with diethyl ether (2×)
3. washwashed with 2 M HCl (2×)
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated