反应详情

Using 4-phenylpiperidine hydrochloride (99 mg, 0.50 mmol) ′and 1-(3-chloropropyl)-4-phenylpiperidine 2 hydrochloride (110 mg, 0.40 mmol) instead of 4-(3-indolyl)piperidine and 1-(3-chloropropyl)-3-(4-methoxyphenyl)piperidine 3 hydrochloride, respectively, the reaction and purification were carried out in the same procedure as Example 2. The resulting crude product was purified by column chromatography on a silica gel (silica gel NH-DM 1020 produced by Fuji Silysia Chemical Ltd., eluent; hexane:ether=2:1) to afford a free form (106 mg) of the title compound as white crystals. After adding hydrochloric acid/methanol to a solution of the free form in methanol, the mixture was concentrated and was then recrystallized from methanol/ether to afford the title compound (113 mg, yield: 65%) as white crystals.

1. customrespectively, the reaction and purification
2. customThe resulting crude product was purified by column chromatography on a silica gel (silica gel NH-DM 1020 produced by Fuji Silysia Chemical Ltd., eluent; hexane:ether=2:1)