反应详情

Into methanol (10 ml) were added (R)-2-(3-chlorophenyl)-2-(3,4,5,6-tetrahydro-[2H]-pyran-2-yloxy)ethyl methanesulfonate (3.0 g) and hydrochloric acid (0.11 g), and the resulting mixture was stirred at room temperature for 3 hours. The reaction mixture was neutralized, concentrated, and ethyl acetate and water were added to the resulting residue. The organic layer was collected by layer separation, washed with a saturated aqueous sodium chloride solution and dried with anhydrous magnesium sulfate. The desiccant was filtered off, and the solvent was distilled off under reduced pressure to obtain a colorless oily compound mentioned above (2.1 g, 93.5%).

1. concentrationconcentrated
2. additionethyl acetate and water were added to the resulting residue
3. customThe organic layer was collected by layer separation
4. washwashed with a saturated aqueous sodium chloride solution
5. dry with materialdried with anhydrous magnesium sulfate
6. filtrationThe desiccant was filtered off
7. distillationthe solvent was distilled off under reduced pressure
8. customto obtain a colorless oily compound