Hydrochloric Acid → HCID 15442724, compound

HRID 479000Notes

Reaction equation

HRID 479000 reaction equation
[CH3:1][S:2]([O:5][CH2:6][C@@H:7]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[CH:16]=1)[O:8]C1CCCCO1)(=[O:4])=[O:3].Cl>CO>[CH3:1][S:2]([O:5][CH2:6][C@@H:7]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[CH:16]=1)[OH:8])(=[O:3])=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10131778HCID 10131778, compound

Product 1

HCID 15442724HCID 15442724, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Into methanol (10 ml) were added (R)-2-(3-chlorophenyl)-2-(3,4,5,6-tetrahydro-[2H]-pyran-2-yloxy)ethyl methanesulfonate (3.0 g) and hydrochloric acid (0.11 g), and the resulting mixture was stirred at room temperature for 3 hours. The reaction mixture was neutralized, concentrated, and ethyl acetate and water were added to the resulting residue. The organic layer was collected by layer separation, washed with a saturated aqueous sodium chloride solution and dried with anhydrous magnesium sulfate. The desiccant was filtered off, and the solvent was distilled off under reduced pressure to obtain a colorless oily compound mentioned above (2.1 g, 93.5%).

Workup

  1. concentrationconcentrated
  2. additionethyl acetate and water were added to the resulting residue
  3. customThe organic layer was collected by layer separation
  4. washwashed with a saturated aqueous sodium chloride solution
  5. dry with materialdried with anhydrous magnesium sulfate
  6. filtrationThe desiccant was filtered off
  7. distillationthe solvent was distilled off under reduced pressure
  8. customto obtain a colorless oily compound

Sources & evidence

ORD record
ord-29900b93d5204a03ad7f1d6b906ff69f
Source dataset
uspto-grants-2003_11
Patent number
US06642395B1

Reaction notes

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