反应详情

A solution of tert-Butyl (3R)-3-[({[(Z)-1-amino-2-ethoxy-2-oxoethylidene]amino}oxy)carbonyl]-6-cyclohexylhexanoate (Preparation 26) (21.0 g, 50.82 mmol) in xylene (400 ml) was heated at 130° C. for 17 hours, then allowed to cool to room temperature. The residue was purified by column chromatography on silica gel eluting with a gradient system of ethyl acetate: pentane (5:95) gradually changing to ethyl acetate: pentane (20:80) to afford the title compound as a colourless oil (20.0 g).

1. customThe residue was purified by column chromatography on silica gel eluting with a gradient system of ethyl acetate: pentane (5:95)