反应详情

The title compound was prepared from 4-(2,4-dioxo-thiazolidin-5-ylmethyl)-benzene-sulfonylchloride (J. Med. Chem. 1992, 35, 1853) and 4-piperidone monohydrate hydrochloride according to the procedure of Intermediate 22 as a white solid; 1H NMR (300 MHz, DMSO-d6) □ 2.40-2.50 (m, 4H), 3.20-3.40 (m, 5H), 3.50 (dd, J=14.1,4.7 Hz, 1H), 5.00 (dd, J=10.4, 4.7 Hz, 1H), 7.56 (d, J=8.4 Hz, 2H), 7.76 (d, J=8.4 Hz, 2H), 12.09 (s, 1H); MS (ES) m/z:368.9 (M++H); HRMS Calcd. for C15H16N2O5S2(M++H): 368.0501. Found: 368.0481. Anal. Calcd. for C15H16N2O5S2: C, 48.90; H, 4.38; N, 7.60. Found: C,48.63; H, 4.35; N, 7.38.