反应详情

A 1.0 M solution of LiAlH4 in THF (6.0 mL, 6.0 mmol) was added dropwise to a suspension of 3-(3-chloro-phenyl)-acrylamide (1.0 g, 5.51 mmol) in 30 mL THF at 0° C. The reaction was warmed to room temperature and was stirred for 5 h. An additional 4 mL of 1 M LiAlH4 was added and the reaction was stirred for 18 h. An addition 2 mL of 1 M LiAlH4 was added and the reaction was stirred for 24 h. The reaction mixture was quenched by dropwise addition of water. The mixture was concentrated in vacuo to remove THF and was diluted with water. The aqueous solution was extracted with EtOAc. The organic solution was washed with water, dried over MgSO4, filtered and concentrated in vacuo. The residue was dissolved in CHCl3 and the organic solution was washed with 1M HCl. The aqueous solution was basified to pH 11 with 1M NaOH and the product was extracted into CHCl3. The organic solution was dried over MgSO4, filtered and concentrated in vacuo to afford the title compound as a yellow oil (0.134 g). 1H NMR (400 MHz, CDCl3) δ 7.20-7.22 (m, 3H),7.16 (m, 1H), 2.74 (t, 2H), 2.61 (t, 2H), 1.74 (m, 2H); MS 170 (M+1).

1. stirringthe reaction was stirred for 18 h
2. additionwas added
3. stirringthe reaction was stirred for 24 h
4. customThe reaction mixture was quenched by dropwise addition of water
5. concentrationThe mixture was concentrated in vacuo
6. customto remove THF
7. additionwas diluted with water
8. extractionThe aqueous solution was extracted with EtOAc
9. washThe organic solution was washed with water
10. dry with materialdried over MgSO4
11. filtrationfiltered
12. concentrationconcentrated in vacuo
13. dissolutionThe residue was dissolved in CHCl3
14. washthe organic solution was washed with 1M HCl
15. extractionthe product was extracted into CHCl3
16. dry with materialThe organic solution was dried over MgSO4
17. filtrationfiltered
18. concentrationconcentrated in vacuo