反应详情

tert-Butyl 2-[3-(allyloxycarbonylmethyl)phenoxy]-2-methylpropionate (3.35 g, 10.62 mmol) was dissolved in methanol (40 mL) and tetrahydrofuran (40 mL). Subsequently, an aqueous 2M sodium hydroxide solution (40 mL) was added thereto, and the mixture was stirred for three hours at room temperature. The resultant mixture was concentrated under reduced pressure, and the resultant concentrate was acidified with 3M hydrochloric acid. The mixture was extracted with chloroform, followed by drying over sodium sulfate and concentration under reduced pressure, whereby the target compound was obtained (2.98 g, 10.12 mmol, 95.5%).

1. concentrationThe resultant mixture was concentrated under reduced pressure
2. concentrationthe resultant concentrate
3. extractionThe mixture was extracted with chloroform
4. dry with materialby drying over sodium sulfate and concentration under reduced pressure, whereby the target compound
5. customwas obtained (2.98 g, 10.12 mmol, 95.5%)