反应详情

In the same manner as that described in Example 3(3), a reaction was carried out using methyl 3-fluoro-4-formylbenzoate (105 mg, 0.58 mmol) obtained in Example 5(1), (2R,3R)-2-(2,4-difluorophenyl)-3-[[1-(hydroxymethyl)-2-hydroxyethyl]thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol (207 mg, 0.58 mmol) and p-toluenesulfonic acid monohydrate (199 mg, 1.04 mmol) and the reaction mixture was treated according to a similar procedure to that described in Example 3(3) to give methyl 4-[trans-5-[[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thio]-1,3-dioxan-2-yl]-3-fluorobenzoate (trans isomer, 106 mg, yield 35%) and methyl 4-[cis-5-[[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thio]-1,3-dioxan-2-yl]-3-fluorobenzoate (cis isomer, 29 mg, yield 10%) as a colorless oil.

1. additionthe reaction mixture was treated