反应详情

In 28 ml of acetic anhydride was dissolved 50.0 g of 2,6-dichlorophenol and, one or two drops of conc. sulfuric acid were added to the solution. The mixture was reacted at 130° C. for 10 minutes to effect acetylation. After the reaction, the reaction solution was poured onto 300 ml of ice water and the mixture was extracted with ethyl acetate. After drying the ethyl acetate phase over anhydrous magnesium sulfate overnight, the ethyl acetate phase was concentrated to give 58.2 g of colorless oily substance. Next, the oily substance was dissolved in 150 ml of nitrobenzene and 56.8 g of powdery aluminum chloride was gradually added to the solution. The reaction was carried out at 60° to 70° C. for 27 hours to effect Fries rearrangement. After completion of the reaction, the reaction solution was poured onto 1 liter of cold dil. hydrochloric acid and the organic phase was separated from the aqueous phase. The organic phase was extracted with 2N sodium hydroxide aqueous solution. After the extraction, the solution was rendered acidic by adding 5N hydrochloric acid thereto followed by extracting with ethyl acetate. After drying over anhydrous magnesium sulfate, the ethyl acetate phase was concentrated to give 38.5 g of 2,6-dichloro-4-acetylphenol as crude crystals. The crystals were recrystallized from hot ethyl acetate to give 19.9 g of pure white 2,6-dichloro-4-acetylphenol. 2,6-Dichloro-4-acetylphenol (3,5-dichloro-4-hydroxyacetophenone): C8H6Cl2O2.

1. additionwere added to the solution
2. customThe mixture was reacted at 130° C. for 10 minutes
3. customAfter the reaction
4. extractionthe mixture was extracted with ethyl acetate
5. dry with materialAfter drying the ethyl acetate phase over anhydrous magnesium sulfate overnight
6. concentrationthe ethyl acetate phase was concentrated
7. customto give 58.2 g of colorless oily substance
8. customAfter completion of the reaction
9. customthe organic phase was separated from the aqueous phase
10. extractionThe organic phase was extracted with 2N sodium hydroxide aqueous solution
11. extractionAfter the extraction
12. additionby adding 5N hydrochloric acid
13. extractionby extracting with ethyl acetate
14. dry with materialAfter drying over anhydrous magnesium sulfate
15. concentrationthe ethyl acetate phase was concentrated