反应详情

5-Bromo-2-(4-aminobutyl)-3-methylpyridine, (0.875 g) and 5-(4-hydroxybenzyl)-2-methylthio-4-pyrimidone (0.745 g) were refluxed in pyridine (3 ml) for 24 hours. The pyridine was evaporated in vacuo. Residual pyridine was removed from the residue by azeotroping with water in vacuo and dried by azeotroping with ethanol. Water (20 ml) was added and the pH lowered to 6 with dilute hydrochloric acid. The solid obtained was recrystallised from ethanol/water, dimethylformamide/water and finally acetic acid/water to give 2-[4-(5-bromo-3-methylpyrid-2-yl)butylamino]-5-(4-hydroxybenzyl)-4-pyrimidone (0.54 g) m.p. 232°-4° C.

1. customThe pyridine was evaporated in vacuo
2. customResidual pyridine was removed from the residue
3. customby azeotroping with water in vacuo
4. customdried
5. customby azeotroping with ethanol
6. additionWater (20 ml) was added
7. customThe solid obtained
8. customwas recrystallised from ethanol/water, dimethylformamide/water and finally acetic acid/water