反应详情

5-Bromo-2-(4-aminobutyl)-3-methylpyridine, (0.88 g) and 5-(3,4-methylenedioxybenzyl)-2-methylthio-4-pyrimidone (0.83 g) were refluxed in pyridine (3 ml) for 24 hours. The pyridine was removed in vacuo and the resulting brown oil triturated with ethanol giving a cream solid which was recrystallised from dimethylformamide/ethanol giving 2-[4-(5-bromo-3-methylpyrid-2-yl)butylamino]-5-(3,4-methylenedioxybenzyl)-4-pyrimidone (1.1 g) as a colourless solid m.p. 145°-6° C.

1. customThe pyridine was removed in vacuo
2. customthe resulting brown oil triturated with ethanol giving a cream solid which
3. customwas recrystallised from dimethylformamide/ethanol