反应详情

Methyl 2-(3-chlorosulfonyl-phenyl)acetate (0.29 g, 1.17 mmol) was dissolved in THF (10 mL) and to this solution 1 mL (2 mmol) of 2M ethylamine in THF was added. Let stir at room temperature 30 minutes, diluted with ethyl acetate and the organic layer was washed with 10% citric acid, brine, dried over sodium sulfate and concentrated to afford (3-ethylsulfamoyl-phenyl)-acetic acid methyl ester as an oil (0.28 g, 1.09 mmol, 93% yield). 1H NMR (CDCl3) 7.72 ppm, 2H, m; 7.41 ppm, 2H, m; 4.32 ppm, 1H, t; 3.68 ppm, 3H, s; 3.67 ppm, 2H, s; 2.98 ppm, 2H, m; 1.07 ppm, 3H, t.

1. additionwas added
2. washthe organic layer was washed with 10% citric acid, brine
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated