反应详情

N-[[[(2,6-Diisopropylphenyl)amino]carbonyl]methyl]-N-pentyl-N-[[2′-[N-(triphenylmethyl)tetrazol-5-yl]-1,1′-biphenyl-4-yl]methyl]amine (278.3 mg) was dissolved in tetrahydrofuran (10 mL), and after addition of 10% hydrochloric acid (3.0 mL), the resulting mixture was stirred at room temperature. Nineteen hours later, the solvent was distilled off, and to the residue, water (30 mL) was added. The mixture so obtained was extracted twice with chloroform (30 mL, each). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was subjected to chromatography on a silica gel column (chloroform/methanol) to afford N-[[[(2,6-diisopropylphenyl) amino]carbonyl]methyl]-N-pentyl-N-[[2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]amine hydrochloride as pale yellow crystals (190.6 mg). Yield: 93%.

1. distillationNineteen hours later, the solvent was distilled off
2. additionto the residue, water (30 mL) was added
3. customThe mixture so obtained
4. extractionwas extracted twice with chloroform (30 mL
5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
6. concentrationconcentrated under reduced pressure