反应详情

Benzyl N-(2-fluoro-4-{6-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyrimidin-4-yloxy}phenyl)carbamate (189 mg) was dissolved in tetrahydrofuran (20 ml). After adding 20% palladium hydroxide-carbon (104 mg), the mixture was stirred for 10 hours under a hydrogen atmosphere. The catalyst was filtered and washed with ethyl acetate. The filtrate and the washings were combined and concentrated under reduced pressure to provide crude 3-[6-(4-amino-3-fluorophenoxy)pyrimidin-4-yl]-1-methyl-1-(1-methylpiperidin-4-yl)urea as a colorless oil [ESI-MS (m/z): 375[M+H]+].

1. filtrationThe catalyst was filtered
2. washwashed with ethyl acetate
3. concentrationconcentrated under reduced pressure