反应详情

After adding 20% palladium hydroxide-carbon (18.3 mg) to a solution of 3-[6-(2-fluoro-4-nitrophenoxy)pyrimidin-4-yl]-1-[1-(2-dimethylaminoethyl)piperidin-4-yl]-1-methylurea (240 mg) in tetrahydrofuran (10 ml), the mixture was stirred for 15.5 hours at room temperature under a hydrogen atmosphere. The catalyst was filtered and washed with methanol. The filtrate was then concentrated to provide the title compound (220 mg, 98.0%) as a yellow amorphous substance.

1. filtrationThe catalyst was filtered
2. washwashed with methanol
3. concentrationThe filtrate was then concentrated