反应详情

4-(2-Fluoro-4-nitrophenoxy)-6-{[4-(1-methylpiperazin-4-yl)piperidin-1-yl]carbonylamino}pyrimidine (104 mg) was dissolved in tetrahydrofuran (15 ml). After adding 20% palladium hydroxide-carbon (70 mg), the mixture was stirred overnight under a hydrogen atmosphere. The catalyst was filtered and washed with tetrahydrofuran. The filtrate and the washings were combined and concentrated under reduced pressure, and the resultant residue was dried under reduced pressure to provide the title compound (98 mg, quantitative) as a pale yellow oil.

1. filtrationThe catalyst was filtered
2. washwashed with tetrahydrofuran
3. concentrationconcentrated under reduced pressure
4. dry with materialthe resultant residue was dried under reduced pressure