反应详情

After adding 20% palladium hydroxide-carbon (50 mg) to a solution of 1-[1-(2-dimethylaminoethyl)piperidin-4-yl]-1-methyl-3-[4-(4-nitrophenoxy)pyridin-2-yl]urea (186 mg) in tetrahydrofuran (5.0 ml), the mixture was stirred for 12 hours at room temperature under a hydrogen atmosphere. The catalyst was filtered. The filtrate was concentrated to provide the title compound (121 mg, 69.8%) as a pale yellow oil.

1. filtrationThe catalyst was filtered
2. concentrationThe filtrate was concentrated