2-CHLORO-3-PIPERAZIN-1-YL-QUINOXALINE → 2-[2-(5-Pyrimidinyloxy)ethoxy]-3-(1-piperazinyl)quinoxaline

HRID 493317Notes

Reaction equation

HRID 493317 reaction equation
Cl[C:2]1[C:11]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[N:18]1[CH:23]=[C:22]([O:24][CH2:25][CH2:26][OH:27])[CH:21]=[N:20][CH:19]=1>>[N:18]1[CH:23]=[C:22]([O:24][CH2:25][CH2:26][O:27][C:2]2[C:11]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)=[N:10][C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)[CH:21]=[N:20][CH:19]=1

Participants

3

Reactant 2

HCID 38468372-CHLORO-3-PIPERAZIN-1-YL-QUINOXALINEHCID 22036262HCID 22036262, compound

Product 1

HCID 220364572-[2-(5-Pyrimidinyloxy)ethoxy]-3-(1-piperazinyl)quinoxaline

Procedure

The title compound was prepared according to the procedure described in Example 162, Step 2, starting from 2-chloro-3-(1-piperazinyl)quinoxaline (0.66 g, 2.65 mmol; from Example 162, Step 1) and 2-(5-pyrimidinyloxy)ethanol (0.45 g, 3.20 mmol). Yield 0.55 g (59%); mp 115-117° C.; HRMS m/z calcd for C18H20N6O2 (M)+ 352.1648, found 352.1654. Anal. (C18H20N6O2) C, H, N.

Sources & evidence

ORD record
ord-a44bcd23f6cd4ec6b82747203ca85a73
Source dataset
uspto-grants-2009_05
Patent number
US07534794B2

Reaction notes

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