HRID49332

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6328

Methyl iodide

CH3I

HCID11430

Potassium Carbonate

CK2O3

$结构：CC/C(=C\CCC(=O)O)c1ccc(COc2ccc(CO[Si](C)(C)C(C)(C)C)c(CO[Si](C)(C)C(C)(C)C)c2)s1$

HCID69825580

未命名化合物

PRODUCTS

生成物

$结构：CC/C(=C\CCC(=O)OC)c1ccc(COc2ccc(CO[Si](C)(C)C(C)(C)C)c(CO[Si](C)(C)C(C)(C)C)c2)s1$

HCID131724375

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6569

Methyl ethyl ketone

C4H8O

PROCEDURE

实验过程

4.3 g (7.1 mmol) of (E)-5-{5-[3,4-bis(tert-butyldimethylsilanyloxymethyl)phenoxymethyl]-2-thienyl}-4-heptenoic acid are dissolved in 70 mL of 2-butanone, and 1.1 g of potassium carbonate (7.8 mmol) and 2.2 mL of iodomethane (35 mmol) are added. The medium is refluxed for 12 hours, cooled and filtered. The filtrate is concentrated under reduced pressure and then purified by chromatography on a column of silica. A yellow oil is obtained (m=4.34 g; Y=98%).

WORKUP

后处理

temperatureThe medium is refluxed for 12 hours
temperaturecooled
filtrationfiltered
concentrationThe filtrate is concentrated under reduced pressure
custompurified by chromatography on a column of silica
customA yellow oil is obtained (m=4.34 g; Y=98%)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b0502686c84e4465bd9abdd4ae24eb3d
来源数据集: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06706725B1
来源说明: uspto-grants-2004_03

反应 SMILES

[Si:1]([O:8][CH2:9][C:10]1[CH:11]=[C:12]([CH:29]=[CH:30][C:31]=1[CH2:32][O:33][Si:34]([C:37]([CH3:40])([CH3:39])[CH3:38])([CH3:36])[CH3:35])[O:13][CH2:14][C:15]1[S:19][C:18](/[C:20](/[CH2:27][CH3:28])=[CH:21]/[CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[CH:17][CH:16]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[C:41](=O)([O-])[O-].[K+].[K+].IC>CC(=O)CC>[Si:1]([O:8][CH2:9][C:10]1[CH:11]=[C:12]([CH:29]=[CH:30][C:31]=1[CH2:32][O:33][Si:34]([C:37]([CH3:39])([CH3:38])[CH3:40])([CH3:35])[CH3:36])[O:13][CH2:14][C:15]1[S:19][C:18](/[C:20](/[CH2:27][CH3:28])=[CH:21]/[CH2:22][CH2:23][C:24]([O:26][CH3:41])=[O:25])=[CH:17][CH:16]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]