反应详情

214 mg (0.6 mmol) 5-(4-Bromo-but-2-enyloxy)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester in 3 ml DMF were treated with 213 mg (3 mmol) N-allylmethylamine at 50° C. for 0.5 h. The mixture was extracted with ether and water. The organic phase was washed with water and dried over Na2SO4 and evaporated to yield 180 mg (83%) 5-[4-(Allyl-methyl-amino)-but-2-enyloxy]-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester as yellow oil, MS: 359 (MH+).

1. extractionThe mixture was extracted with ether and water
2. washThe organic phase was washed with water
3. dry with materialdried over Na2SO4
4. customevaporated