Sodium sulfate decahydrate → 2-[3,5-Bis(methoxymethoxy)phenyl]ethanol

HRID 495172Notes

Reaction equation

[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][O:8][CH2:9][O:10][C:11]1[CH:12]=[C:13]([CH2:21][C:22](OC)=[O:23])[CH:14]=[C:15]([O:17][CH2:18][O:19][CH3:20])[CH:16]=1.O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>O1CCCC1>[CH3:7][O:8][CH2:9][O:10][C:11]1[CH:12]=[C:13]([CH2:21][CH2:22][OH:23])[CH:14]=[C:15]([O:17][CH2:18][O:19][CH3:20])[CH:16]=1

Participants

Conditions

Temperature: 4 °C

Procedure

A solution of lithium aluminum hydride (1.0 g, 26 mmol) in tetrahydrofuran (50 mL) was cooled to 4° C., and a solution of methyl 3,5-bis(methoxymethoxy)phenylacetate (5.3 g, 20 mmol) obtained in Example 1, Step 1 in tetrahydrofuran (50 mL) was added dropwise thereto, followed by stirring at 4° C. for 30 minutes. To the reaction mixture was added anhydrous sodium sulfate decahydrate to stop the reaction, and the mixture was stirred at room temperature for 12 hours. The resulting suspension was filtered under reduced pressure, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate/hexane=1/9-1/1) to obtain 2-[3,5-bis(methoxymethoxy)phenyl]ethanol (4.6 g, 98%). 1H-NMR (CDCl3, 270 MHz) δ (ppm): 6.62 (t, J=2.2 Hz, 1H), 6.58 (d, J=2.2 Hz, 2H), 5.14 (s, 4H), 3.85 (q, J=6.4 Hz, 2H), 3.48 (s, 6H), 2.81 (t, J=6.4 Hz, 2H), 1.42 (t, J=6.4 Hz, 1H)

Workup

customthe reaction
stirringthe mixture was stirred at room temperature for 12 hours
filtrationThe resulting suspension was filtered under reduced pressure
concentrationthe filtrate was concentrated under reduced pressure
customThe resulting residue was purified by silica gel column chromatography (ethyl acetate/hexane=1/9-1/1)

Sources & evidence

ORD record: ord-dddd94960aa248a087382fb7e7a89322
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07538224B2

Reaction notes

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