反应详情

Using the method in Example 154, this compound was prepared from methyl 3-(2-hydroxy-5-oxo-5,6,7,8-tetrahydro-1-naphthalenyl)methylsulfanylbenzoate (1.81 g, 5.3 mmol), (R)-2-imidazol-1-yl-1-phenylethanol (1.00 g, 5.3 mmol), Ph3P (2.10 g, 8.0 mmol), and diethyl azodicarboxylate (1.39 g, 8.0 mmol) and purified by a silica-column (eluting with dichloromethane-MeOH 20:1) as a solid-foam, 2.56 g, 94% yield; mp 65° C. NMR spectrum was consistent with structure. Calcd. For C30H28N2O4S.0.5H2O:

1. custompurified by a silica-column (eluting with dichloromethane-MeOH 20:1) as a solid-foam, 2.56 g, 94% yield