反应详情

Under an atmosphere of protective gas, 3.5 g of 5-benzoyloxy-3-chloro-2-hydroxy-1-iodobenzene, 2.07 g of 3-(5-trifluoromethylpyrid-2-yloxy)propan-1-ol and 2.57 g of triphenylphosphine were dissolved in 100 ml of dry tetrahydrofuran (THF). With ice-bath cooling, 1.71 g of diethyl azodicarboxylate were added dropwise. After about 30 minutes, the ice-bath was removed, and the mixture was stirred at room temperature for 15 hours. The mixture was then concentrated under reduced pressure and the residue was taken up in a mixture of ethyl acetate and water. After shaking, the organic phase was isolated, dried and concentrated under reduced pressure. The crude product was purified chromatographically. Yield: 3.12 g (58%)

1. temperatureWith ice-bath cooling
2. customthe ice-bath was removed
3. concentrationThe mixture was then concentrated under reduced pressure
4. additionthe residue was taken up in a mixture of ethyl acetate and water
5. stirringAfter shaking
6. customthe organic phase was isolated
7. customdried
8. concentrationconcentrated under reduced pressure
9. customThe crude product was purified chromatographically