反应详情

[(1S, 2S)-2-Methyl-1-(3,3,4,4-tetrafluoro-pyrrolidine-1-carbonyl)-butyl]-carbamic acid tert-butyl ester (200 mg, 0.56 mmol) was dissolved in ethyl acetate (4 mL), cooled to ° C. and treated with gaseous HCl for about 1 minute. After 15 minute at 0° C. and 30 minute at room temperature, the mixture was concentrated to dryness and the solid was triturated with hexane, collected and dried under vacuum overnight (124 mg, 76%, mp>250° C.).

1. temperaturecooled
2. concentration30 minute at room temperature, the mixture was concentrated to dryness
3. customthe solid was triturated with hexane
4. customcollected
5. customdried under vacuum overnight (124 mg, 76%, mp>250° C.)