反应详情

温度

-40 °C

To a solution of (S)-2-(3,5-dichloro-phenyl)-10,10a-dihydro-5H-imidazo[1,5-b]isoquinoline-1,3-dione (100 mg) (0.1 mmol) (Prep. 22) in 2.5 mL of dry THF at −40° C. was added a 1 M solution of LIHMDS (0.5 mL) in THF. The reaction mixture was stirred for 15 min. at −40° C. and a solution of 4-bromobenzyl bromide (70 mg) in 1 mL of dry THF was added. The reaction mixture was stirred at −50 C. for 30 min., allowed to warm to RT, stirred overnight, then partitioned between brine and t-Bu methyl ether. The organic layer was dried over MgSO4, concentrated in vacuo, and the residue purified by HPLC to afford the above compound (34.5 mg). NMR (CDCl3, 200 MHz): 7.45 (2H, d), 7.25-7.35 (5H, m), 6.95-7.0 (4H, d+d), 5.15 (1H, d), 4.55 (1H, d), 3.25 (2H, s), 3.20 (1H, d), 2.95 (1H, d).

1. stirringThe reaction mixture was stirred at −50 C
2. waitfor 30 min.
3. temperatureto warm to RT
4. stirringstirred overnight
5. custompartitioned between brine and t-Bu methyl ether
6. dry with materialThe organic layer was dried over MgSO4
7. concentrationconcentrated in vacuo
8. customthe residue purified by HPLC