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HRID500386

反应详情

EQUATION

反应方程式

HRID 500386 的结构方程式

REACTANTS

反应物

2
结构：O=C(Cl)c1cccc(Oc2ccccc2)c1
HCID2760341

3-phenoxybenzoyl chloride

C13H9ClO2

结构：CC(C)(C)OC(=O)NC1COCCCC=CC2CC2(C(=O)NS(=O)(=O)C2CC2)NC(=O)C2CC(O)CN2C1=O
HCID72260127

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NC1COCCCC=CC2CC2(C(=O)NS(=O)(=O)C2CC2)NC(=O)C2CC(OC(=O)c3cccc(Oc4ccccc4)c3)CN2C1=O
HCID72445371

未命名化合物

收率 16%

PROCEDURE

实验过程

Prepared by way of method I using 18-hydroxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo[14.3.0.04,6]-nonadec-7-ene (100 mg, 0.175 mmol) and 3-phenoxybenzoyl chloride (122 μL, 0.53 mmol). The final trituration (diethyl ether/hexane) and filtration gave 21 mg (16%) of 18-(3-phenoxybenzoyloxy)-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo-[14.3.0.04,6]-nonadec-7-ene as a white powder: 98.0% pure (HPLC), MS m/z 765 (M−H)−, HRMS: calcd. 767.2962 and found 767.2971 (M+H)+, mp 123-125° C.

WORKUP

后处理

  1. customPrepared by way of method I
  2. filtrationThe final trituration (diethyl ether/hexane) and filtration