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HRID500409

反应详情

EQUATION

反应方程式

HRID 500409 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)NC1COCCCC=CC2CC2(C(=O)NS(=O)(=O)C2CC2)NC(=O)C2CC(O)CN2C1=O
HCID72260127

未命名化合物

结构：O=C=CCOc1ccccc1N=C=O
HCID86612087

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NC1COCCCC=CC2CC2(C(=O)NS(=O)(=O)C2CC2)NC(=O)C2CC(OC(=O)N(OCC=C=O)c3ccccc3)CN2C1=O
HCID86612086

未命名化合物

收率 27.1%

PROCEDURE

实验过程

Prepared by way of method III using 18-hydroxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo[14.3.0.04,6]-nonadec-7-ene (100 mg, 0.175 mmol) and 2-carbonylethoxyphenyl isocyanate (102 mg, 0.53 mmol). The final trituration (diethyl ether/hexane) and filtration gave 18 mg (14%) of 18-(2-carbonylethoxyphenylaminocarbonyloxy)-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo-[14.3.0.04,6]-nonadec-7-ene as a white powder: 98.9% pure (HPLC), MS m/z 758 (M−H)−, HRMS: calcd. 760.3228 and found 760.3226 (M+NH4)+, mp 148-150° C.

WORKUP

后处理

  1. customPrepared by way of method III
  2. filtrationThe final trituration (diethyl ether/hexane) and filtration