HRID50070

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID22741726

未命名化合物

结构：CC(=O)N(C)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCCN(C(=O)c3ccccc3)C2)CC1.Cl

HCID22741746

未命名化合物

PRODUCTS

生成物

结构：Cl.Cl.Nc1nc(C2(c3ccccc3)CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCCN(C(=O)c4ccccc4)C3)CC2)cs1

HCID22741719

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21891449

未命名化合物

PROCEDURE

实验过程

This compound is prepared by the procedure described in step D of EXAMPLE 13, starting from 0.77 g of 4-(2-aminothiazol-4-yl)-4-phenylpiperidine (compound of PREPARATION 1.4 in the form of the free base), 1.2 g of the compound obtained in step C of EXAMPLE 13 and 1.2 g of K2CO3 in 20 ml of a DMF/acetonitrile mixture (50/50; v/v). This gives 0.8 g of the expected product after crystallization from AcOEt, m.p.=178° C.

WORKUP

后处理

customThis compound is prepared by the procedure
customThis gives 0.8 g of the expected product after crystallization from AcOEt, m.p.=178° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c6df22f1889c4041802a2753354318ba
来源数据集: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06710042B2
来源说明: uspto-grants-2004_03

反应 SMILES

[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[N:6]=1.[ClH:19].C(N(C1(C2C=CC=CC=2)CCN([CH2:31][CH2:32][CH2:33][C:34]2([C:49]3[CH:54]=[CH:53][C:52]([Cl:55])=[C:51]([Cl:56])[CH:50]=3)[CH2:40][CH2:39][CH2:38][CH2:37][N:36]([C:41](=[O:48])[C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=3)[CH2:35]2)CC1)C)(=O)C.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.C(#N)C>[ClH:55].[ClH:19].[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:8][CH2:9][N:10]([CH2:31][CH2:32][CH2:33][C:34]3([C:49]4[CH:54]=[CH:53][C:52]([Cl:55])=[C:51]([Cl:56])[CH:50]=4)[CH2:40][CH2:39][CH2:38][CH2:37][N:36]([C:41](=[O:48])[C:42]4[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=4)[CH2:35]3)[CH2:11][CH2:12]2)[N:6]=1