反应详情

Starting from the compound 259 and following the procedures described above for the synthesis of compound 262b (scheme 60, step 4, example 219) but using benzyl bromide in step 1 instead of methyl iodide, title compound 262c was obtained. 1H NMR (DMSO-d6) δ (ppm): 12.36 (s, 1H), 11.76(s, 1H), 7.78(m, 1H,), 7.58(t, 1H, J1=J2=2.7 Hz), 7.50(d, 1H, J=5.7 Hz), 7.34(m, 5H), 7.30-7.221(m, 5H), 7.15(dd, 1H, J1=8.1 Hz, J2=0.4 Hz), 7.10(t, 1H), 6.60(d, 1H, J=2.9 Hz), 5.68(s, 2H), 3.82(s, 2H). MS (m/z): 511.2(M+H) (found).