反应详情

A mixture of 2-benzyl-1,2,3,4-tetrahydro[1]benzofuro[2,3-c]pyridine (0.2 g, 0.75 mmol) and methyl chloroformate (0.358 g, 3.787 mmol) in dichloroethane (15 mL) was refluxed for 1 h. The reaction mixture was cooled to room temperature and washed with saturated NaHCO3 (25 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to furnish methyl 3,4-dihydro[1]benzofuro[2,3-c]pyridine-2(1H)-carboxylate (0.150 g, 85.7%). 1H NMR (200 MHz, CDCl3): δ 2.70-2.76 (m, 2H), 3.80 (s, 5H), 4.72 (m, 2H), 7.22 (m, 2H), 7.42 (m, 2H).

1. temperaturewas refluxed for 1 h
2. washwashed with saturated NaHCO3 (25 mL)
3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated