反应详情

2-Bromo-6-fluoroaniline (8.2 g, 43.2 mmol) was dissolved in pyridine (10 mL) and treated with pivaloyl chloride (7.0 mL, 57.2 mmol). The reaction was stirred at room temperature for 3 h. The reaction mixture was concentrated in vacuo and treated with ethyl acetate (50 mL). Mixture was washed 1 N hydrochloric acid (2×), then brine. The organic layer was dried (magnesium sulfate), filtered, and concentrated in vacuo. The residue was triturated with hexanes to give a solid which was filtered, washed with hexanes, and dried in vacuo. The title compound was obtained as white solid in 76% yield. 1H NMR (300 MHz, CDCl3): δ 7.39-7.31 (m, 1H), 7.14-7.03 (m, 2H), 6.98 (bs, 1H), 1.34 (s, 9H). Mass spec.: 274.1 (MH)+, 276.1 (MNa)+.

1. concentrationThe reaction mixture was concentrated in vacuo
2. additiontreated with ethyl acetate (50 mL)
3. washMixture was washed 1 N hydrochloric acid (2×)
4. dry with materialThe organic layer was dried (magnesium sulfate)
5. filtrationfiltered
6. concentrationconcentrated in vacuo
7. customThe residue was triturated with hexanes
8. customto give a solid which
9. filtrationwas filtered
10. washwashed with hexanes
11. customdried in vacuo