反应详情

温度

85 °C

To a suspension of 2-(4-aminophenyl)-1-cyclobutyl-6-hydroxy-1H-indole-3-carbonitrile (519.2 mg, 1.71 mmol), K2CO3, 10 mL of methyl ethyl ketone, and 2 mL of DMF is added 2-bromoethyl methyl ether. The resulting mixture is stirred at 85° C. for 8 h. The mixture is concentrated and the residue is partitioned between ethyl acetate (20 mL) and water (20 mL). The aqueous phase is extracted with additional ethyl acetate (20 mL). The combined organic phases are washed with saturated NaCl, dried over MgSO4, and then the solution is concentrated and the product is washed with diethyl ether to afford 505.0 mg (81.7% yield) of 2-(4-aminophenyl)-1-cyclobutyl-6-(2-methoxy-ethoxy)-1H-indole-3-carbonitrile as a yellow solid.

1. concentrationThe mixture is concentrated
2. customthe residue is partitioned between ethyl acetate (20 mL) and water (20 mL)
3. extractionThe aqueous phase is extracted with additional ethyl acetate (20 mL)
4. washThe combined organic phases are washed with saturated NaCl
5. dry with materialdried over MgSO4
6. concentrationthe solution is concentrated
7. washthe product is washed with diethyl ether