反应详情

A solution of N-{3-[({[3-({2-({6-[(5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-oxo-1,3-oxazolidin-3-yl]hexyl}oxy)ethoxy}methyl)phenyl]amino}carbonyl)-amino]phenyl}pyridine-3-carboxamide (0.209 g) in anhydrous THF (10 ml) was treated under nitrogen at 200 with potassium trimethylsilanolate (0.217 g). The mixture was heated to 650 for 2.5 h before cooling to room temperature. Phosphate buffer (pH 6.5, 25 ml) was added and the product extracted with EtOAc (3×20 ml). Solvent evaporation in vacuo gave a residue that was purified by SPE. Elution with dichloromethane-EtOH-ammonia (100:8:1 then 50:8:1) followed by solvent evaporation in vacuo gave the title compound (0.109 g). LCMS RT=2.86 min, ES+ve 712 (MH)+.

1. temperatureThe mixture was heated to 650 for 2.5 h
2. extractionthe product extracted with EtOAc (3×20 ml)
3. customSolvent evaporation in vacuo
4. customgave a residue that
5. customwas purified by SPE
6. washElution with dichloromethane-EtOH-ammonia (100:8:1
7. custom50:8:1) followed by solvent evaporation in vacuo