反应详情

2-(1-Benzothien-2-yl)-5-nitrobenzamide (4.75 g) is introduced into THF (250 ml) and, after addition of platinum dioxide (0.57 g), hydrogenated at RT under atmospheric pressure overnight. The reaction mixture is filtered through kieselguhr and washed with THF, and the organic phase is concentrated. The residue is stirred with diethyl ether, and the crystals are filtered off with suction. They are washed with diethyl ether and a little DCM and dried. Yield 2.39 g (56% of theory).

1. customhydrogenated at RT
2. customunder atmospheric pressure overnight
3. filtrationThe reaction mixture is filtered through kieselguhr
4. washwashed with THF
5. concentrationthe organic phase is concentrated
6. filtrationthe crystals are filtered off with suction
7. washThey are washed with diethyl ether
8. dry with materiala little DCM and dried