Formic Acid → 2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethyl)benzaldehyde

HRID 505257Notes

Reaction equation

HRID 505257 reaction equation
[F:1][C:2]([F:34])([F:33])[C:3]1[CH:4]=[C:5]([C@H:13]2[O:17][C:16](=[O:18])[N:15]([CH2:19][C:20]3[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:25]=[CH:24][C:21]=3[C:22]#N)[C@H:14]2[CH3:32])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.C(O)=[O:36]>O=[Pt]=O>[F:1][C:2]([F:34])([F:33])[C:3]1[CH:4]=[C:5]([C@H:13]2[O:17][C:16](=[O:18])[N:15]([CH2:19][C:20]3[CH:27]=[C:26]([C:28]([F:29])([F:30])[F:31])[CH:25]=[CH:24][C:21]=3[CH:22]=[O:36])[C@H:14]2[CH3:32])[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=1

Participants

4

Reactant 2

HCID 284Formic AcidHCID 866287512-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethyl)benzonitrile

Product 1

HCID 576178812-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethyl)benzaldehyde

Reagents, catalysts & solvents 1

HCID 345198Adams' catalystCatalyst3×

Conditions

Temperature
60 °C

Procedure

To a solution of 2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethyl)benzonitrile (242.1 mg, 0.488 mmol) in 88% aqueous formic acid (5.86 mL) was added PtO2 (57 mg, 0.251 mmol). The reaction was heated to 60° C. After 2 hours, additional PtO2 (57 mg, 0.251 mmol) was added. After 2 more hours, a third portion of PtO2 (57 mg, 0.251 mmol) was added. Heating of the reaction at 60° C. was continued for 18 more hours, and then the reaction was cooled to room temperature. The catalyst was removed by filtration through celite with THF (50 mL). The filtrate was diluted with EtOAc (100 mL) and washed with H2O (2×50 mL), 1:1 saturated NaHCO3/brine (2×50 mL), and brine (50 mL). The organic layer was dried over Na2SO4, filtered, and concentrated. Purification of the residue by flash chromatography (5 to 35% EtOAc/hexanes) afforded 2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethyl)benzaldehyde. Rf=0.23 (25% EtOAc/hexanes). LCMS=500.0 (M+1)+. 1H NMR (CDCl3, 500 MHz) δ 10.26 (s, 1H), 7.79-8.02 (m, 6H), 5.74 (d, J=8.1 Hz, 1H), 5.08 (d, J=16.5 Hz, 1H), 4.91 (d, J=16.7 Hz, 1H), 4.18 (m, 1H), 0.81 (d, J=6.4 Hz, 3H).

Workup

  1. temperatureHeating of the reaction at 60° C.
  2. temperaturethe reaction was cooled to room temperature
  3. customThe catalyst was removed by filtration through celite with THF (50 mL)
  4. additionThe filtrate was diluted with EtOAc (100 mL)
  5. washwashed with H2O (2×50 mL), 1:1 saturated NaHCO3/brine (2×50 mL), and brine (50 mL)
  6. dry with materialThe organic layer was dried over Na2SO4
  7. filtrationfiltered
  8. concentrationconcentrated
  9. customPurification of the residue by flash chromatography (5 to 35% EtOAc/hexanes)

Sources & evidence

ORD record
ord-1de7eed1bdcd429090996dc4b0c925b6
Source dataset
uspto-grants-2010_08
Patent number
US07781426B2

Reaction notes

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