1,1-Dichloroethane → (4s,5r)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-[2-[(diethylamino)methyl]-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

HRID 505281Notes

Reaction equation

HRID 505281 reaction equation
[F:1][C:2]([F:34])([F:33])[C:3]1[CH:4]=[C:5]([C@H:13]2[O:17][C:16](=[O:18])[N:15]([CH2:19][C:20]3[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:25]=[CH:24]C=3C=O)[C@H]2C)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[NH:35]([CH2:38][CH3:39])[CH2:36][CH3:37].[BH-](OC(C)=O)(OC(C)=O)O[C:42]([CH3:44])=O.[Na+].Cl[CH:55](Cl)[CH3:56]>CCOC(C)=O>[F:1][C:2]([F:33])([F:34])[C:3]1[CH:4]=[C:5]([C@H:13]2[O:17][C:16](=[O:18])[N:15]([CH2:19][C:20]3[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:25]=[CH:24][C:37]=3[CH2:36][N:35]([CH2:42][CH3:44])[CH2:38][CH3:39])[C@H:55]2[CH3:56])[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=1

Participants

6

Reactant 4

HCID 63651,1-DichloroethaneHCID 8021DiethylamineHCID 5049666Sodium triacetoxyborohydrideHCID 576178812-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethyl)benzaldehyde

Product 1

HCID 24896004(4s,5r)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-[2-[(diethylamino)methyl]-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethyl)benzaldehyde (14.5 mg, 0.0291 mmol) in dichloroethane (300 μL) was added HNEt2 (4.6 μL, 0.0436 mmol), and NaBH(OAc)3 (9.2 mg, 0.0436 mmol). The reaction was stirred at room temperature for 18 hours and then diluted with EtOAc (10 mL) and washed with brine (5 mL). The organic layer was dried over Na2SO4, filtered, and concentrated. Purification of the residue by PTLC (50% EtOAc/hexanes) afforded (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-[(diethylamino)methyl]-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one. Rf=0.57 (50% EtOAc/hexanes). LCMS=557.2 (M+1)+. 1H NMR (CDCl3, 500 MHz) δ 7.92 (s, 1H), 7.82 (s, 2H), 7.55-7.52 (m, 3H), 5.76 (d, J=8.0 Hz, 1H), 5.03 (d, J=16.1 Hz, 1H), 4.60 (d, J=16.1 Hz, 1H), 4.05-4.03 (m, 1H), 3.73 (d, J=13.5 Hz, 1H), 3.57 (d, J=13.7 Hz, 1H), 2.75-2.56 (m, 4H), 1.04 (bs, 6H), 0.80 (d, J=6.4 Hz, 3H).

Workup

  1. washwashed with brine (5 mL)
  2. dry with materialThe organic layer was dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customPurification of the residue by PTLC (50% EtOAc/hexanes)

Sources & evidence

ORD record
ord-d0e9ea6bb19c4ed9a6dda3eef0e7310b
Source dataset
uspto-grants-2010_08
Patent number
US07781426B2

Reaction notes

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