HRID505492

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID603502

未命名化合物

结构：COC(=O)[C@@H](N)Cc1ccc(OCCc2nc(-c3ccccc3)oc2C)c(Br)c1

HCID68445645

未命名化合物

PRODUCTS

生成物

结构：Cc1oc(-c2ccccc2)nc1CCOc1ccc(C[C@H](NC(=O)C=Cc2ccc(F)cc2F)C(=O)O)cc1Br

HCID68445081

未命名化合物

收率 31%

PROCEDURE

实验过程

Following the procedures described in Example 1, Intermediate 3B was used in place of Intermediate 3A, and 2,4-difluorocinnamic acid was used in place of cinnamic acid to give (2S)-3-{3-bromo-4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-phenyl}-2-(3-(2,4-difluorophenyl)-acryloylamino)-propanoic acid as a white solid with the yield of 31% and mp of 221-223° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-10d6a3de7e074de0aba304d2292fc9cc
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07781468B2
来源说明: uspto-grants-2010_08

反应 SMILES

C[O:2][C:3](=[O:29])[C@@H:4]([NH2:28])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH2:14][C:15]2[N:16]=[C:17]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[O:18][C:19]=2[CH3:20])=[C:8]([Br:27])[CH:7]=1.[F:30][C:31]1[CH:41]=[C:40]([F:42])[CH:39]=[CH:38][C:32]=1[CH:33]=[CH:34][C:35](O)=[O:36]>>[Br:27][C:8]1[CH:7]=[C:6]([CH2:5][C@H:4]([NH:28][C:35](=[O:36])[CH:34]=[CH:33][C:32]2[CH:38]=[CH:39][C:40]([F:42])=[CH:41][C:31]=2[F:30])[C:3]([OH:2])=[O:29])[CH:11]=[CH:10][C:9]=1[O:12][CH2:13][CH2:14][C:15]1[N:16]=[C:17]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[O:18][C:19]=1[CH3:20]