反应详情

A solution (1.74 M) of methyl 5-methyl-4-nitrothiophene-2-carboxylate (prepared as described in example 1, step 1) in MeOH, was treated with 4-chlorobenzaldehyde (1.5 eq.). The reaction mixture was heated to reflux and when it became a clear solution, a catalytic amount of pyrrolidine (0.10 eq.) was added. The reaction mixture was heated to reflux overnight. After cooling down, evaporation of the solvent gave a residue that was triturated with petroleum ether/Et2O and filtered to afford the title compound title compound (67%) as a solid.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux
3. temperatureThe reaction mixture was heated
4. temperatureto reflux overnight
5. temperatureAfter cooling down
6. customevaporation of the solvent
7. customgave a residue that
8. customwas triturated with petroleum ether/Et2O
9. filtrationfiltered