HRID506815

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16219689

2-(1-Methyl-1H-imidazol-5-yl)ethan-1-amine--hydrogen chloride (1/2)

C6H13Cl2N3

结构：COc1cc2c(nc1OC)c(-c1cc3c(C=O)ccnc3n1S(=O)(=O)c1ccc(C)cc1)cn2C

HCID86618635

未命名化合物

PRODUCTS

生成物

结构：COc1cc2c(nc1OC)c(-c1cc3c(CNCCc4cncn4C)ccnc3n1S(=O)(=O)c1ccc(C)cc1)cn2C

HCID68469651

未命名化合物

收率 95.4%

PROCEDURE

实验过程

The product is prepared by following the procedure described in example 34 stage (j) starting with 0.06 g of 2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-carbaldehyde and 0.05 g of 3-methylhistamine dihydrochloride instead of the cyclopropylamine used in example 34 stage (j). After purification by flash-pack chromatography (SiO2, dichloromethane/methanol 98/02 by volume as eluents), 0.070 g of [2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-[2-(3-methyl-3H-imidazol-4-yl)-ethyl]amine is obtained with the following characteristics:

WORKUP

后处理

customThe product is prepared
customAfter purification by flash-pack chromatography (SiO2, dichloromethane/methanol 98/02 by volume as eluents)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4d2557e25521411eb250d1891bf4037f
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07786114B2
来源说明: uspto-grants-2010_08

反应 SMILES

[CH3:1][O:2][C:3]1[N:8]=[C:7]2[C:9]([C:13]3[N:23]([S:24]([C:27]4[CH:32]=[CH:31][C:30]([CH3:33])=[CH:29][CH:28]=4)(=[O:26])=[O:25])[C:16]4[N:17]=[CH:18][CH:19]=[C:20]([CH:21]=O)[C:15]=4[CH:14]=3)=[CH:10][N:11]([CH3:12])[C:6]2=[CH:5][C:4]=1[O:34][CH3:35].Cl.Cl.[CH3:38][N:39]1[C:43]([CH2:44][CH2:45][NH2:46])=[CH:42][N:41]=[CH:40]1>>[CH3:1][O:2][C:3]1[N:8]=[C:7]2[C:9]([C:13]3[N:23]([S:24]([C:27]4[CH:28]=[CH:29][C:30]([CH3:33])=[CH:31][CH:32]=4)(=[O:25])=[O:26])[C:16]4=[N:17][CH:18]=[CH:19][C:20]([CH2:21][NH:46][CH2:45][CH2:44][C:43]5[N:39]([CH3:38])[CH:40]=[N:41][CH:42]=5)=[C:15]4[CH:14]=3)=[CH:10][N:11]([CH3:12])[C:6]2=[CH:5][C:4]=1[O:34][CH3:35]