反应详情

Free base of the titled compound was prepared from 2-styryl-1H-benzimidazole and 2-fluoro-4-methylpyridine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base was treated with a 10% methanol solution of hydrogen chloride and concentrated to dryness. The residue was recrystallized from ethyl acetate/n-hexane to give the titled compound. MW: 358.68; mp: 221.0-222.5° C.; 1H-NMR (DMSO) δ: 8.66 (1H, d, J=5.1 Hz), 8.22-8.15 (1H, m), 7.86 (1H, d, J=7.7 Hz), 7.71-7.66 (3H, m), 7.59-7.44 (7H, m), 7.20 (1H, d, J=16.1 Hz), 2.53 (3H, s).

1. concentrationconcentrated to dryness
2. customThe residue was recrystallized from ethyl acetate/n-hexane