Ammonia → 2-chloro-6-fluoro-N'-(4-iodophenyl)benzenecarbohydrazonamide

HRID 508716Notes

Reaction equation

HRID 508716 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9](Cl)=[N:10][NH:11][C:12]1[CH:17]=[CH:16][C:15]([I:18])=[CH:14][CH:13]=1.[NH3:20]>C1COCC1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9](=[N:10][NH:11][C:12]1[CH:17]=[CH:16][C:15]([I:18])=[CH:14][CH:13]=1)[NH2:20]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 1317332342-chloro-6-fluoro-N-(4-iodophenyl)benzenecarbohydrazonoyl chloride

Product 1

HCID 1179654592-chloro-6-fluoro-N'-(4-iodophenyl)benzenecarbohydrazonamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared according to the procedure described in step-3 of Intermediate-1 by using 2-chloro-6-fluoro-N-(4-iodophenyl)benzenecarbohydrazonoyl chloride (1.00 g, 2.44 mmol), aq. ammonia (2.0 mL) and dry THF (10 mL) to afford 0.900 g of the desired product. 1H NMR (300 MHz, DMSO d6): δ 6.28 (br s, 2H), 6.70 (d, J=8.4 Hz, 2H), 7.27 (t, J=8.7 Hz, 1H), 7.36-7.42 (m, 3H), 7.45-7.51 (m, 1H), 8.33 (s, 1H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-82c25862119c45a49a8715978854bbaa
Source dataset
uspto-grants-2015_08
Patent number
US09096545B2

Reaction notes

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