反应详情

Free base of the titled compound was prepared from 2-styryl-1H-benzimidazole and 2-Chloro-6-methylpyridine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base was treated with a 10% methanol solution of hydrogen chloride and concentrated to dryness. The residue was recrystallized from ethyl acetate/n-hexane to give the titled compound. MW: 347.85; mp: 216.0-217.0° C.; 1H-NMR (DMSO-d6) δ: 8.20 (1H, br s), 8.10 (1 H, t, J=7.7 Hz), 7.87 (1H, d, J=7.7 Hz), 7.71-7.44 (10H, m), 7.22 (1H, d, J=16.1 Hz), 2.63 (3H, s).

1. concentrationconcentrated to dryness
2. customThe residue was recrystallized from ethyl acetate/n-hexane