反应详情

Free base of the titled compound was prepared from 2-styryl-1H-benzimidazole and 4,6-dichloropyrimidine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base was treated with a 10% methanol solution of hydrogen chloride and concentrated to dryness. The residue was recrystallized from ethyl acetate-hexane to give the titled compound. MW: 376.33; mp: 203.0-204.0° C.; 1H-NMR (DMSO) δ: 9.27 (1H, d, J=1.1 Hz), 8.15 (1H, d, J=1.1 Hz), 8.02-7.94 (1H, m), 7.80-7.72 (4H, m), 7.49-7.27 (6H, m).

1. concentrationconcentrated to dryness
2. customThe residue was recrystallized from ethyl acetate-hexane