Sodium Hydroxide → 7-(3-(3-Trifluoromethyl-7-propyl-6-benz-[4,5]-isoxazoloxy)propoxy)-2-ethylchromane-2-carboxylic Acid

HRID 51076ノート

反応式

HRID 51076 の反応式
[F:1][C:2]([F:38])([F:37])[C:3]1[C:7]2[CH:8]=[CH:9][C:10]([O:15][CH2:16][CH2:17][CH2:18][O:19][C:20]3[CH:29]=[C:28]4[C:23]([CH2:24][CH2:25][C:26]([CH2:35][CH3:36])([C:30]([O:32]CC)=[O:31])[O:27]4)=[CH:22][CH:21]=3)=[C:11]([CH2:12][CH2:13][CH3:14])[C:6]=2[O:5][N:4]=1.[OH-].[Na+]>C(O)(C)C>[F:38][C:2]([F:1])([F:37])[C:3]1[C:7]2[CH:8]=[CH:9][C:10]([O:15][CH2:16][CH2:17][CH2:18][O:19][C:20]3[CH:29]=[C:28]4[C:23]([CH2:24][CH2:25][C:26]([CH2:35][CH3:36])([C:30]([OH:32])=[O:31])[O:27]4)=[CH:22][CH:21]=3)=[C:11]([CH2:12][CH2:13][CH3:14])[C:6]=2[O:5][N:4]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 69898123Ethyl 7-(3-(3-trifluoromethyl-7-propyl-6-benz-[4,5]-isoxazoloxy)propoxy)-2-ethylchromane-2-carboxylate

生成物 1

HCID 101857347-(3-(3-Trifluoromethyl-7-propyl-6-benz-[4,5]-isoxazoloxy)propoxy)-2-ethylchromane-2-carboxylic Acid収率 100.7%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

Ethyl 7-(3-(3-trifluoromethyl-7-propyl-6-benz-[4,5]-isoxazoloxy)propoxy)-2-ethylchromane-2-carboxylate (49 mg, 0.092 mmol) was dissolved in isopropanol 2 ml and 2N NaOH aq. 1 ml and was stirred at 70° C. overnight. The solvent was removed under reduced pressure. The residue was diluted with AcOEt and 2N HCl aq. The organic layer was separated, and the aqueous layer was extracted twice with AcOEt. The combined organic layers were dried over anhydrous Na2SO4, filtered, and concentrated to give the title compound 47 mg as a pale yellow oil (quant.).

後処理

  1. customThe solvent was removed under reduced pressure
  2. additionThe residue was diluted with AcOEt and 2N HCl aq. The organic layer
  3. customwas separated
  4. extractionthe aqueous layer was extracted twice with AcOEt
  5. dry with materialThe combined organic layers were dried over anhydrous Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-bf7fc24e18f848318131251554373777
出典データセット
uspto-grants-2004_03
特許番号
US06713508B2

反応ノート

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