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HRID511048

反应详情

EQUATION

反应方程式

HRID 511048 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O
HCID85083

1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-

C10H17NO4

结构：CC(O)c1ccc([C@H]2C[C@@]3(C)[C@@H](CC[C@@]3(O)C(F)(F)C(F)(F)F)[C@@H]3CCC4=CC(=O)CCC4=C32)cc1
HCID18346565

未命名化合物

PRODUCTS

生成物

1
结构：CC(OC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)c1ccc([C@H]2C[C@@]3(C)[C@@H](CC[C@@]3(O)C(F)(F)C(F)(F)F)[C@@H]3CCC4=CC(=O)CCC4=C32)cc1
HCID86670524

未命名化合物

收率 78%

PROCEDURE

实验过程

In analogy to Example 5, 330 mg (0.65 mmol) of (8S,11R,13S,14S,17S)-17-hydroxy-11-[4-((RS)-1-hydroxyethyl)phenyl]-13-methyl-17-pentafluoroethyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one were converted using (S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester and, after workup and purification, 356 mg (78%) of the title compounds were isolated as a colourless foam.

WORKUP

后处理

  1. customafter workup and purification