反应详情

The diethyl [2-(4-nitrophenyl)propan-2-yl]phosphonate (103 mg) prepared as described above, was hydrogenated in the presence of 10% Pd/C (50 mg) in MeOH (5 mL) for 4 h. The mixture was filtered and the filtrate concentrated in vacuo to afford 92.5 mg of the desired diethyl [2-(4-aminophenyl)propan-2-yl]phosphonate (yield: 99%), which was used in further chemistries without purification. 1H-NMR (CDCl3, 400 MHz): δ=1.20 (t, J=7.2 Hz, 6 H), 1.54 (s, 3 H), 1.59 (s, 3 H), 3.65 (s, br, 2 H), 3.80-3.94 (m, 2 H), 6.66 (d, J=8.8 Hz, 2 H), 7.32 (dd, J=2.4, 8.8 Hz, 2 H). MS (ES+): m/z 272.02 (MH+). HPLC: tR=2.45 min (ZQ3, polar—5 min).

1. filtrationThe mixture was filtered
2. concentrationthe filtrate concentrated in vacuo