反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
PROCEDURE
实验过程
This compound was prepared in a manner analogous to Example 87 using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate and 7-amino-2-methyl-4-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-2,3-dihydro-1H-isoindol-1-one. 1H NMR (CDCl3, 400 MHz): δ=1.25-1.30 (m, 6 H), 1.40-1.55 (m, 2 H), 1.62 (q, J=12.80 Hz, 2 H), 1.97 (d, J=12.63 Hz, 2 H), 2.13 (d, J=11.87 Hz, 2 H), 2.37 (s, 3 H), 2.50 (d, J=12.13 Hz, 2 H), 2.61 (br. s., 2 H), 2.77 (br. s., 3 H), 3.14-3.20 (m, 2 H), 3.22 (s, 3 H), 3.93 (s, 3 H), 4.00-4.10 (m, 4 H), 4.38 (s, 2 H), 6.89 (dt, J=8.15, 2.24 Hz, 1 H), 6.94 (t, J=2.02 Hz, 1 H), 7.34 (d, J=8.59 Hz, 1 H), 7.63 (s, 1 H), 8.29 (d, J=8.59 Hz, 1 H), 8.39 (s, 1 H), 8.63 (d, J=8.59 Hz, 1 H), 10.50 (s, 1 H). MS (ES+): m/z 760.32 [MH+]; HPLC: tR=1.20 min (UPLC TOF MS: polar—3 min).
WORKUP
后处理
- customHPLC: tR=1.20 min (UPLC TOF MS: polar—3 min)